A perspective on AKT 25-plus years after its discovery

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A perspective on AKT 25-plus years after its discovery.

Since its discovery more than 25 years ago, the kinase AKT has become a central figure in cell signaling. We highlight some of the landmark findings in those 25 years that contributed to our understanding of the regulation and function of AKT in directing cellular processes and behavior. Future progress toward fully understanding the roles of AKT in cell, tissue, and organismal biology will dep...

متن کامل

Thematic minireview series: a perspective on the biology of phosphoenolpyruvate carboxykinase 55 years after its discovery.

Much has been published over the years on the enzymology, genetics, and metabolic role of the enzyme phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32), and much of it has been in the Journal of Biological Chemistry. It is thus not an accident that the Journal is again focusing on this important enzyme in a Compendium that includes the original article by Utter and Kurahashi describin...

متن کامل

Blood Circulation 400 Years after its Discovery

INTRODUCTION Modern medical science was born in the Post-Renaissance or counter-reformation era and began to consolidate in the mid-seventeenth century thanks to the work of physicists, physiologists and biologists who were direct or indirect disciples of Galileo. At that time there was a tendency for scientific studies to move away from conservative and traditionalist universities to concentra...

متن کامل

Filariasis in Japan Some 25 Years after its Eradication

Japan is said to have eradicated filariasis some 25 years ago, but the exact time (and even the definition of eradication) is not clear. However, the results of successful control programs clearly indicate that the number of microfilaria carriers had been reduced to a very low level long before the “eradication”. As filariasis disappeared, the once stigmatized disease quickly lost clinical sign...

متن کامل

Fructose 2,6-bisphosphate 2 years after its discovery.

It was in 1909 that Young, in the laboratory of Harden, isolated from fermenting yeast the fructose bisphosphate (the Harden and Young ester) that was later identified by Levene & Raymond (1928) as fructose 1,6-bisphosphate. Some 71 years elapsed until a second fructose bisphosphate was isolated from living cells and identified as fructose 2,6bisphosphate (Van Schaftingen et al., 1980c). In con...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Science Signaling

سال: 2017

ISSN: 1945-0877,1937-9145

DOI: 10.1126/scisignal.aan8791